Monday August 13, 2007
Ischemia Modified Albumin (IMA)

When we look at the standard coronary disease predictors (Troponin-I & CK-MB) we are looking at values that reflect necrosis. In one small study the use of IMA along with Myoglobin, CK-MB, & Troponin-I increased the sensativity of detecting an ischemic event to 97% with a negative predictive value of 92%. Similar other reports in literature are also posing for this test to be an integral part of cardiac events in future (see references).


Above pearl contributed from:

Ken Davis at Eastern New Mexico University - Roswell (DAVISKE@roswell.enmu.edu)



References: click to get abstract/article

1. Role of "Ischemia Modified Albumin", a new biochemical marker of myocardial ischaemia, in the early diagnosis of acute coronary syndromes - Emerg Med J 2004; 21:29-34
2. Ischemia-Modified Albumin and Myocardial Ischemia - Kalay et al. J Am Coll Cardiol.2007; 49: 2375
3. Utility of admission cardiac troponin and "Ischemia Modified Albumin" measurements for rapid evaluation and rule out of suspected acute myocardial infarction in the emergency department - Emergency Medicine Journal 2006;23:256-261
4. "Ischemia modified albumin": a new biochemical marker of myocardial ischaemia Emerg Med J.2004; 21: 3-4
5. "Ischemia modified albumin" from thedoctorsdoctor.com